Theoretical Evaluation of the Interactions between Metal-Phthalocyanines and Various Fullerenes asDelivery Systems by Oana-Raluca Pop & Jacobus (Koos) Frederick Van Staden
Author:Oana-Raluca Pop & Jacobus (Koos) Frederick Van Staden
Format: pdf
Tags: The photodynamic therapy (PDT) represents a non-invasive method with good results in the treatment of superficial tumors. PDT is based on a combination of two factors, namely, a non-toxic photosensitizing molecule and a light source; the photosensitizer absorbs a photon of radiation, leading to a series of reactions that cause irreversible damage to the affected tissue. The present paper investigates the photosensitization properties of nine substituted metal-phthalocyanines (the central metals being iron, nickel, and zinc). In addition, the interactions between the aforementioned compounds and four fullerenes are investigated by means of molecular docking studies in order to verify their potential as delivery systems for phthalocyanines. Our results outline that the properties of metal-phthalocyanines are mainly influenced by the type of substituent and to a lesser extent by the nature of the metal. The binding energies of the metal-phthalocyanines towards the fullerenes suggest a slight increased affinity for the fullerene C52 as compared to the three nitrogen- and phosphorus-doped C46N3P3 fullerenes., metal-phthalocyanine; fullerenes; delivery system; ab initio
Download
This site does not store any files on its server. We only index and link to content provided by other sites. Please contact the content providers to delete copyright contents if any and email us, we'll remove relevant links or contents immediately.
Rewire Your Anxious Brain by Catherine M. Pittman(17777)
Talking to Strangers by Malcolm Gladwell(12186)
The Art of Thinking Clearly by Rolf Dobelli(9150)
Mindhunter: Inside the FBI's Elite Serial Crime Unit by John E. Douglas & Mark Olshaker(8067)
Becoming Supernatural by Dr. Joe Dispenza(7279)
The Road Less Traveled by M. Scott Peck(6825)
Change Your Questions, Change Your Life by Marilee Adams(6815)
Nudge - Improving Decisions about Health, Wealth, and Happiness by Thaler Sunstein(6789)
The Lost Art of Listening by Michael P. Nichols(6676)
Enlightenment Now: The Case for Reason, Science, Humanism, and Progress by Steven Pinker(6538)
Mastermind: How to Think Like Sherlock Holmes by Maria Konnikova(6453)
Win Bigly by Scott Adams(6449)
The Way of Zen by Alan W. Watts(5945)
Daring Greatly by Brene Brown(5828)
Big Magic: Creative Living Beyond Fear by Elizabeth Gilbert(4903)
Grit by Angela Duckworth(4877)
Altered Sensations by David Pantalony(4566)
Men In Love by Nancy Friday(4524)
Ego Is the Enemy by Ryan Holiday(4271)